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Article

MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS.

PloS one - 1 Jan 2012

O'Reilly Paul F, Hoggart Clive J, Pomyen Yotsawat, Calboli Federico C F, Elliott Paul, Jarvelin Marjo-Riitta, Coin Lachlan J M

Abstract excerpt

The genome-wide association study (GWAS) approach has discovered hundreds of genetic variants associated with diseases and quantitative traits. However, despite clinical overlap and statistical correlation between many phenotypes, GWAS are generally performed one-phenotype-at-a-time. Here we compare the performance of modelling multiple phenotypes jointly with that of the standard univariate approach. We...

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PMID: 22567092
DOI: 10.1371/journal.pone.0034861
PMCID: PMC3342314

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