Article

Detecting genetic effects on phenotype variability to capture gene-by-environment interactions: a systematic method comparison

2023-06-09

Abstract excerpt

Phenotypic variability has been widely observed across organisms and traits, including in humans. Both gene-gene and gene-environment interactions can lead to an increase in phenotypic variability. Therefore, detecting the underlying genetic variants, or variance Quantitative Trait Loci (vQTLs), can provide novel insights into complex traits. Established approaches to detect vQTLs apply different methodologies fro...

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Literature Corpus work: aa307bd6-acf8-5906-8b24-e4255cafccf0
DOI: 10.1101/2023.06.09.544298

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