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Article

A Functional Approach to Testing Overall Effect of Interaction Between DNA Methylation and SNPs.

Statistics in medicine - 1 Jan 2026

Gansou Yvelin, Oualkacha Karim, Angela Cremona Marzia, Lakhal-Chaieb Lajmi

Abstract excerpt

We introduce a test for the overall effect of interaction between DNA methylation and a set of single nucleotide polymorphisms on a quantitative phenotype. The developed inference procedure is based on a functional approach that extend existing regression models in functional data analysis. Through extensive simulations, we show that the proposed test effectively controls type I error rates and highlights...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41572586
DOI: 10.1002/sim.70364
PMCID: PMC12828112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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