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Article

Statistical Impact of Sample Size and Imbalance on Multivariate Analysis in silico and A Case Study in the UK Biobank.

AMIA ... Annual Symposium proceedings. AMIA Symposium - 1 Jan 2020

Zhang Xinyuan, Li Ruowang, Ritchie Marylyn D

Abstract excerpt

Large-scale biobank cohorts coupled with electronic health records offer unprecedented opportunities to study genotype-phenotype relationships. Genome-wide association studies uncovered disease-associated loci through univariate methods, with the focus on one trait at a time. With genetic variants being identifiedfor thousands of traits, researchers found that 90% of human genetic loci are associated with more...

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PMID: 33936514
PMCID: PMC8075427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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