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Article

pgainsim: an R-package to assess the mode of inheritance for quantitative trait loci in GWAS.

Bioinformatics (Oxford, England) - 29 Sept 2021

Scherer Nora, Sekula Peggy, Pfaffelhuber Peter, Schlosser Pascal

Abstract excerpt

MOTIVATION: When performing genome-wide association studies conventionally the additive genetic model is used to explore whether a single nucleotide polymorphism (SNP) is associated with a quantitative trait. But for variants, which do not follow an intermediate mode of inheritance (MOI), the recessive or the dominant genetic model can have more power to detect associations and furthermore the MOI is important...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33738486
DOI: 10.1093/bioinformatics/btab150
PMCID: PMC8479659

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