Article

Identifying SNP associations and predicting disease risk from Genome-wide association studies using LassoNet

2021-08-30

Abstract excerpt

In this paper, we show that under certain conditions LassoNet [1] should outperform threshold of significance (P-value) methods for identifying multi-SNP disease associations and predicting disease risk using data from Genome Wide Association Studies. To demonstrate this, we built a genotype-phenotype simulation to comprehensively benchmark each method’s performance in variant selection and in predicting disease r...

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Literature Corpus work: a92d6af1-79b6-57ee-bae2-eea841c0b1ff
DOI: 10.1101/2021.08.29.458051

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