Article
A test for gene-environment interaction in the presence of measurement error in the environmental variable.
Genetic epidemiology - 1 Apr 2018
Aschard Hugues, Spiegelman Donna, Laville Vincent, Kraft Pete, Wang Molin
Abstract excerpt
The identification of gene-environment interactions in relation to risk of human diseases has been challenging. One difficulty has been that measurement error in the exposure can lead to massive reductions in the power of the test, as well as in bias toward the null in the interaction effect estimates. Leveraging previous work on linear discriminant analysis, we develop a new test of interaction between genetic...
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