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Article

Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism.

NeuroImage - 15 Oct 2010

Donix Markus, Burggren Alison C, Suthana Nanthia A, Siddarth Prabha, Ekstrom Arne D, Krupa Allison K, Jones Michael, Rao Anup, Martin-Harris Laurel, Ercoli Linda M, Miller Karen J, Small Gary W, Bookheimer Susan Y

Abstract excerpt

People with the apolipoprotein-Eepsilon4 (APOE-4) genetic risk for Alzheimer's disease show morphologic differences in medial temporal lobe regions when compared to non-carriers of the allele. Using a high-resolution MRI and cortical unfolding approach, our aim was to determine the rate of cortical thinning among medial temporal lobe subregions over the course of 2 years. We hypothesized that APOE-4 genetic risk...

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Source

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Identifiers

PMID: 20541611
DOI: 10.1016/j.neuroimage.2010.06.009
PMCID: PMC3118546

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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