Article

A spatially-specific pattern of cortical thickness in frontal lobe predisposes to faster future amyloid accumulation in individuals with subjective cognitive decline

2026-07-17

Abstract excerpt

The risk of developing AD is conferred through numerous genetic and environmental factors. How these risks influence brain structure prior to the onset of AD pathology is not yet known. We hypothesise that there may be specific anatomic endophenotypes that predispose to AD years before the first signs of amyloid accumulation occur. Using clinical, genetic and brain MRI data from Fundació ACE Healthy Brain Initiati...

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Literature Corpus work: aaf6ddde-0484-5280-9001-d810d2e9e94b
DOI: 10.64898/2026.07.11.737919

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