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Article

Family history of Alzheimer's disease and hippocampal structure in healthy people.

The American journal of psychiatry - 1 Nov 2010

Donix Markus, Burggren Alison C, Suthana Nanthia A, Siddarth Prabha, Ekstrom Arne D, Krupa Allison K, Jones Michael, Martin-Harris Laurel, Ercoli Linda M, Miller Karen J, Small Gary W, Bookheimer Susan Y

Abstract excerpt

OBJECTIVE: Structural brain changes appear years before the onset of Alzheimer's disease, the leading cause of dementia late in life. Determining risk factors for such presymptomatic brain changes may assist in identifying candidates for future prevention treatment trials. In addition to the e4 allele of the apolipoprotein E gene (APOE-4), the major known genetic risk factor, a family history of Alzheimer's...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20686185
DOI: 10.1176/appi.ajp.2010.09111575
PMCID: PMC3086166

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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