Article
Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs.
Journal of experimental & clinical cancer research : CR - 25 May 2010
Pasche Boris, Wisinski Kari B, Sadim Maureen, Kaklamani Virginia, Pennison Michael J, Zeng Qinghua, Bellam Naresh, Zimmerman Jacquelyn, Yi Nengjun, Zhang Kui, Baron John, Stram Daniel O, Hayes M Geoffrey
Abstract excerpt
PURPOSE: Constitutively decreased TGFBR1 allelic expression is emerging as a potent modifier of colorectal cancer risk in mice and humans. This phenotype was first observed in mice, then in lymphoblastoid cell lines from patients with microsatellite stable colorectal tumors. PATIENTS AND METHODS: We assessed the frequency of constitutively decreased TGFBR1 allelic expression and association with SNPs covering the...
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