Article
Lack of an association between the TGFBR1*6A variant and colorectal cancer risk.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2007
Skoglund Johanna, Song Bo, Dalén Johan, Dedorson Stefan, Edler David, Hjern Fredrik, Holm Jörn, Lenander Claes, Lindforss Ulrik, Lundqvist Nils, Olivecrona Hans, Olsson Louise, Påhlman Lars, Rutegård Jörgen, Smedh Kennet, Törnqvist Anders, Houlston Richard S, Lindblom Annika
Abstract excerpt
PURPOSE: Recently a common variant of the TGFBR1 gene, TGFBR1*6A, has been proposed to act as a low-penetrance tumor susceptibility allele for colorectal cancer, but data from published studies with individually low statistical power are conflicting. To further evaluate the relationship between TGFBR1*6A and colorectal cancer risk, we have conducted a large case-control study and a meta-analysis of previously...
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