Article
Bioinformatic and functional analysis of TGFBR1 polymorphisms.
Pharmacogenetics and genomics - 1 Apr 2009
Schirmer Markus A, Hoffmann Arne O, Campean Radu, Janke Jörg H, Zidek Laura M, Hoffmann Marion, Kruse Moritz, Sehrt Daniel, Tzvetkov Mladen V, Rave-Fränk Margret, Brockmöller Jürgen
Abstract excerpt
OBJECTIVES: The transforming growth factor-beta (TGFB) pathway has substantial impact on cellular functions, cell proliferation, and apoptosis. We used bioinformatics, gene expression, and cell biological assays to evaluate the functionality of frequent inherited germline polymorphisms in the TGFB receptor 1 (TGFBR1). METHODS: In an exploratory (n=55) and confirmatory (n=106) study, we analyzed the TGFB1 pathway...
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