Article
Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients.
Cancer research - 15 Jun 2009
Guda Kishore, Natale Leanna, Lutterbaugh James, Wiesner Georgia L, Lewis Susan, Tanner Stephan M, Tomsic Jerneja, Valle Laura, de la Chapelle Albert, Elston Robert C, Willis Joseph, Markowitz Sanford D
Abstract excerpt
Recently, germline allele-specific expression (ASE) of the gene encoding for transforming growth factor-beta type I receptor (TGFBR1) has been proposed to be a major risk factor for cancer predisposition in the colon. Germline ASE results in a lowered expression of one of the TGFBR1 alleles (>1.5-fold), and was shown to occur in approximately 20% of informative familial and sporadic colorectal cancer (CRC) cases....
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