Article
Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer.
Science (New York, N.Y.) - 5 Sept 2008
Valle Laura, Serena-Acedo Tarsicio, Liyanarachchi Sandya, Hampel Heather, Comeras Ilene, Li Zhongyuan, Zeng Qinghua, Zhang Hong-Tao, Pennison Michael J, Sadim Maureen, Pasche Boris, Tanner Stephan M, de la Chapelle Albert
Abstract excerpt
Much of the genetic predisposition to colorectal cancer (CRC) in humans is unexplained. Studying a Caucasian-dominated population in the United States, we showed that germline allele-specific expression (ASE) of the gene encoding transforming growth factor-beta (TGF-beta) type I receptor, TGFBR1, is a quantitative trait that occurs in 10 to 20% of CRC patients and 1 to 3% of controls. ASE results in reduced...
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