Somatic acquisition and signaling of TGFBR1*6A in cancer.

doi:10.1001/jama.294.13.1634

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Article

Somatic acquisition and signaling of TGFBR1*6A in cancer.

JAMA - 5 Oct 2005

Pasche Boris, Knobloch Thomas J, Bian Yansong, Liu Junjian, Phukan Sharbani, Rosman Diana, Kaklamani Virginia, Baddi Lisa, Siddiqui Farida S, Frankel Wendy, Prior Thomas W, Schuller David E, Agrawal Amit, Lang Jas, Dolan M Eileen, Vokes Everett E, Lane William S, Huang Chiang-Ching, Caldes Trinidad, Di Cristofano Antonio, Hampel Heather, Nilsson IngMarie, von Heijne Gunnar, Fodde Riccardo, Murty V V V S, de la Chapelle Albert, Weghorst Christopher M

Abstract excerpt

CONTEXT: TGFBR1*6A is a common polymorphism of the type I transforming growth factor beta receptor (TGFBR1). Epidemiological studies suggest that TGFBR1*6A may act as a tumor susceptibility allele. How TGFBR1*6A contributes to cancer development is largely unknown. OBJECTIVES: To determine whether TGFBR1*6A is somatically acquired by primary tumors and metastases during cancer development and whether the 3-amino...

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Identifiers

PMID: 16204663
DOI: 10.1001/jama.294.13.1634

Genes

TGFBR1
DLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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