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Article

TGFBR1 and cancer susceptibility.

Transactions of the American Clinical and Climatological Association - 1 Jan 2014

Pasche Boris, Pennison Michael J, Jimenez Hugo, Wang Minghui

Abstract excerpt

Transforming growth factor beta (TGF-β) is a potent inhibitor of cell growth. TGFBR1 6A is a polymorphism consisting of a 9-base pair in-frame deletion within exon 1 of the type I TGF-β receptor (TGFBR1), which results in a receptor with decreased TGF-β signaling capability. The discovery of an association between TGFBR1*6A and cancer susceptibility led to the hypothesis that hypomorphic variants of the TGF-β...

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Source

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Identifiers

PMID: 25125747
PMCID: PMC4112675

Genes

TGFBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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