Comprehensive assessment of variation at the transforming growth factor beta type 1 receptor locus and colorectal cancer predisposition.

doi:10.1073/pnas.1002816107

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Article

Comprehensive assessment of variation at the transforming growth factor beta type 1 receptor locus and colorectal cancer predisposition.

Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 2010

Carvajal-Carmona Luis G, Churchman Mike, Bonilla Carolina, Walther Axel, Lefèvre Jeremie H, Kerr David, Dunlop Malcolm, Houlston Richard, Bodmer Walter F, Tomlinson Ian

Abstract excerpt

The role of transforming growth factor beta receptor type 1 (TGFBR1) polymorphisms, particularly a coding CGC insertion (rs11466445, TGFBR1*6A/9A) in exon 1, has been extensively investigated in regard to colorectal cancer (CRC) risk. These investigations have generated conflicting results. More recently, allele-specific expression (ASE) of TGFBR1 mRNA has been suggested as predisposing to CRC, with a relative...

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PMID: 20368424
DOI: 10.1073/pnas.1002816107
PMCID: PMC2867909

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TGFBR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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