Article
A haplotype of TGFBR1 is predominantly found in non-small cell lung cancer patients displaying TGFBR1 allelic-specific expression.
Oncology reports - 1 Mar 2011
Sun Jinxia, Lei Zhe, Liu Reng-Yun, Lu Yufeng, Zhuang Zhixiang, Jiang Xiefang, Qian Qian, Liu Zeyi, Zhao Jun, Zhang Hong-Tao
Abstract excerpt
Non-small cell lung cancer (NSCLC) accounts for ~85% of all cases of lung cancer and TGF-ß refractoriness is very common in NSCLC cells. Constitutively decreased TGFBR1 expression, probably leading to TGF-ß resistance in tumors, is emerging as a novel tumor-predisposing phenotype. However, the pr...
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