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Article

TGFBR1 intralocus epistatic interaction as a risk factor for colorectal cancer.

PloS one - 1 Jan 2012

Martinez-Canto Ana, Castillejo Adela, Mata-Balaguer Trinidad, Castillejo Maria-Isabel, Hernandez-Illan Eva, Irles Esperanza, Barbera Victor Manuel, Egoavil Cecilia, Guarinos Carla, Alenda Cristina, Ochoa Enrique, Lazaro Rafael, Fajardo Silvia, Lacueva Javier, Calpena Rafael, Soto Jose Luis

Abstract excerpt

In colorectal cancer (CRC), an inherited susceptibility risk affects about 35% of patients, whereas high-penetrance germline mutations account for <6% of cases. A considerable proportion of sporadic tumors could be explained by the coinheritance of multiple low-penetrance variants, some of which are common. We assessed the susceptibility to CRC conferred by genetic variants at the TGFBR1 locus. We analyzed 14...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Transforming Growth Factor-beta Type I

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Source

Open in PubMed Open full text

Identifiers

PMID: 22292045
DOI: 10.1371/journal.pone.0030812
PMCID: PMC3264637

Genes

TGFBR1

Provenance

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