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Article

Allele-specific expression of TGFBR1 in colon cancer patients.

Carcinogenesis - 1 Oct 2010

Tomsic Jerneja, Guda Kishore, Liyanarachchi Sandya, Hampel Heather, Natale Leanna, Markowitz Sanford D, Tanner Stephan M, de la Chapelle Albert

Abstract excerpt

The genetic component of colorectal cancer (CRC) predisposition has been only partially explained. We recently suggested that a subtle decrease in the expression of one allele of the TGFBR1 gene was a heritable quantitative trait predisposing to CRC. Here, we refined the measurements of allele-specific expression (ASE) of TGFBR1 in a population-based series of CRC patients and controls. Five single-nucleotide...

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Share to Protein Serine-Threonine Kinases
Share to Quantitative Trait, Heritable

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Alleles

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Share to Gene Expression Regulation, Neoplastic

Share to Receptor, Transforming Growth Factor-beta Type I

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Source

Open in PubMed Open full text

Identifiers

PMID: 20705955
DOI: 10.1093/carcin/bgq165
PMCID: PMC2950937

Genes

TGFBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allele-specific expression of TGFBR1 in colon cancer patients.PMID 20705955Read ↗

Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients.Semantic proximity Read ↗

Comprehensive assessment of variation at the transforming growth factor beta type 1 receptor locus and colorectal cancer predisposition.Semantic proximity Read ↗

Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer.Semantic proximity Read ↗

No association between germline allele-specific expression of TGFBR1 and colorectal cancer risk in Caucasian and Ashkenazi populations.Semantic proximity Read ↗

Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs.Semantic proximity Read ↗

TGFBR1 intralocus epistatic interaction as a risk factor for colorectal cancer.Semantic proximity Read ↗

A haplotype of TGFBR1 is predominantly found in non-small cell lung cancer patients displaying TGFBR1 allelic-specific expression.Semantic proximity Read ↗

TGFBR1 and cancer susceptibility.Semantic proximity Read ↗

Lack of an association between the TGFBR1*6A variant and colorectal cancer risk.Semantic proximity Read ↗

The TGFBR1*6A allele is not associated with susceptibility to colorectal cancer in a Spanish population: a case-control study.Semantic proximity Read ↗

Little evidence for association between the TGFBR1*6A variant and colorectal cancer: a family-based association study on non-syndromic family members from Australia and Spain.Semantic proximity Read ↗

Colorectal cancers in patients with the (9A/6A) polymorphism of TGFBR1 exhibit lesser inter-(simple sequence repeat) PCR genomic instability and present clinically at greater age.Semantic proximity Read ↗

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