Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms.

doi:10.1111/j.1530-0277.2011.01714.x

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Article

Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms.

Alcoholism, clinical and experimental research - 1 Jul 2012

Koller Gabriele, Zill Peter, Rujescu Dan, Ridinger Monika, Pogarell Oliver, Fehr Christoph, Wodarz Norbert, Bondy Brigitta, Soyka Michael, Preuss Ulrich W

Abstract excerpt

BACKGROUND: Several lines of evidence from previous research indicate that opioid receptors play an important role in ethanol reinforcement and alcohol dependence (AD) risk. Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism. METHODS: We investigated a total number of 1,845 alcohol-dependent subjects recruited...

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Identifiers

PMID: 22309038
DOI: 10.1111/j.1530-0277.2011.01714.x

Genes

OPRM1

Variants

rs1799971

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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