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Article

Mouse model of the OPRM1 (A118G) polymorphism: differential heroin self-administration behavior compared with wild-type mice.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 13 Mar 2015

Zhang Yong, Picetti Roberto, Butelman Eduardo R, Ho Ann, Blendy Julie A, Kreek Mary Jeanne

Abstract excerpt

Mu-opioid receptors (MOPRs) are the target of heroin and other prescription opioids, which are currently responsible for massive addiction morbidity in the US. The gene coding for the human MOPR (OPRM1) has an important functional single nucleotide polymorphism (SNP), A118G. The OPRM1 A118G genotype results in substantially increased risk of heroin addiction in humans; however, the neurobiological mechanism for...

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Identifiers

PMID: 25336208
DOI: 10.1038/npp.2014.286
PMCID: PMC4367451

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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