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Article

Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the micro-opioid receptor gene locus.

Biological psychiatry - 1 Jan 2010

Barr Christina S, Chen Scott A, Schwandt Melanie L, Lindell Stephen G, Sun Hui, Suomi Stephen J, Heilig Markus

Abstract excerpt

BACKGROUND: The role of a nonsynonymous A118G polymorphism of the human micro-opioid receptor gene (OPRM1) for alcohol reward and therapeutic efficacy of naltrexone remains controversial. A functionally equivalent OPRM1 C77G polymorphism in rhesus macaques allows this to be addressed under controlled experimental conditions. METHODS: Twenty-one rhesus macaques (13 female rhesus macaques, 8 male rhesus macaques)...

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Source

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Identifiers

PMID: 19748082
DOI: 10.1016/j.biopsych.2009.07.026
PMCID: PMC2794913

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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