Article
Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults.
Addiction biology - 1 Jan 2016
Hendershot Christian S, Claus Eric D, Ramchandani Vijay A
Abstract excerpt
Human laboratory and animal models implicate variation in the μ-opioid receptor gene (OPRM1) as relevant for alcohol-related reward. OPRM1 is associated with alcohol self-administration in non-human primate studies, but the relevance of this finding to human models is unclear. This study used computer-assisted self-infusion of ethanol (CASE) to examine associations among OPRM1 A118G genotype, subjective responses...
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