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Article

A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology.

Translational psychiatry - 26 Jul 2016

Bernardi R E, Zohsel K, Hirth N, Treutlein J, Heilig M, Laucht M, Spanagel R, Sommer W H

Abstract excerpt

It has been proposed that vulnerability to nicotine addiction is moderated by variation at the μ-opioid receptor locus (OPRM1), but results from human studies vary and prospective studies based on genotype are lacking. We have developed a humanized mouse model of the most common functional OPRM1 polymorphism rs1799971_A>G (A118G). Here we use this model system together with a cohort of German youth to examine the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27459726
DOI: 10.1038/tp.2016.132
PMCID: PMC5545715

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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