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Article

Frequent changes in subtelomeric DNA methylation patterns and its relevance to telomere regulation during human hepatocarcinogenesis

19 Apr 2010

Abstract excerpt

Subtelomeric chromatin modifications are important regulators of telomere length. We examined the subtelomeric DNA methylation status of 7q, 8q, 17q, 18p, 21q and XpYp in 32 pairs of hepatocellular carcinomas (HCCs) and their adjacent non-HCCs via methylation-specific PCR (quantified as methylation ratio). In addition, 10q was subjected to bisulfite-genomic-sequencing. Telomere length was determined by Southern...

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Share to Epigenetics and DNA Methylation
Share to Genomic variations and chromosomal abnormalities
Share to Telomeres, Telomerase, and Senescence

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PMID: 20473888
DOI: 10.1002/ijc.25398

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