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Article

Aging-Associated Alteration of Subtelomeric Methylation in Parkinson's Disease

5 Jun 2009

Abstract excerpt

A telomere is a repetitive DNA structure capping the chromosomal ends. Telomeres stabilize the chromosome structure and prevent harmful end-to-end recombinations. The telomere length of somatic cells can be determined as the terminal restriction fragment length provided by a genomic Southern blotting analysis, and the telomere length becomes shorter at each mitotic cycle due to an "end-replication problem."...

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Share to Epigenetics and DNA Methylation
Share to Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19502593
DOI: 10.1093/gerona/glp070

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