Selective increase in subtelomeric DNA methylation: an epigenetic biomarker for malignant glioma

Abstract excerpt

BACKGROUND: Subtelomeric regions dynamically change their epigenetic pattern during development and progression of several malignancies and degenerative disorders. However, DNA methylation of human subtelomeres and their correlation to telomere length (TL) remain undetermined in glioma. RESULTS: Herein, we report on the selective changes in subtelomeric DNA methylation at the end of five chromosomes (Chr.) (7q,...

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