Genetic Instability and Aberrant Dna Methylation in Chronic Hepatitis and Cirrhosis—A Comprehensive Study of Loss of Heterozygosity and Microsatellite Instability At 39 Loci and Dna Hypermethylation on 8 Cpg Islands in Microdissected Specimens From Patients With Hepatocellular Carcinoma

Abstract excerpt

A study was conducted to examine the significance of genetic instability and aberrant DNA methylation during hepatocarcinogenesis. Genomic DNA was extracted from 196 microdissected specimens of noncancerous liver tissue that showed no marked histologic findings or findings compatible with chronic hepatitis or cirrhosis, and 80 corresponding microdissected specimens of hepatocellular carcinoma (HCC) from 40...

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