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Age-Related Changes in Subtelomeric Methylation in the Normal Japanese Population

17 Feb 2009

Abstract excerpt

BACKGROUND: The telomeres of somatic cells become shorter with individual aging. However, no significant change in subtelomeric methylation of somatic cells with aging has yet been reported. METHODS: Telomere lengths of the peripheral blood cells of 148 normal Japanese were analyzed by Southern blotting using methylation-sensitive and -insensitive isoschizomers. RESULTS: With aging, long telomeres decrease and...

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Share to Epigenetics and DNA Methylation
Share to Genomics and Chromatin Dynamics
Share to Telomeres, Telomerase, and Senescence

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PMID: 19223605
DOI: 10.1093/gerona/gln057

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