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Article

Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis.

The American journal of pathology - 1 Oct 2003

Lee Sun, Lee Hyeon Joo, Kim Jae-Hoon, Lee Hyo-Suk, Jang Ja June, Kang Gyeong Hoon

Abstract excerpt

To determine the methylation profile of multiple tumor-related genes during multistep hepatocarcinogenesis, we investigated the methylation status of CpG islands of 9 genes, using methylation-specific polymerase chain reaction for 60 paired hepatocellular carcinoma (HCC) and non-HCC liver tissue samples, 22 dysplastic nodule (DN), 30 liver cirrhosis (LC), 34 chronic hepatitis (CH) and 20 normal liver samples. The...

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Identifiers

PMID: 14507645
DOI: 10.1016/S0002-9440(10)63495-5
PMCID: PMC1868296

Genes

GSTP1
APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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