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Article

The Alteration of Subtelomeric DNA Methylation in Aging-Related Diseases

9 Jan 2019

Abstract excerpt

The telomere is located at the end of the chromosome and consists of a non-coding, repetitive DNA sequence. As the cell divides, the length of telomere gradually decreases. A very short telomere can terminate mitosis, and thus telomere length becomes a hallmark of cellular aging. The 500 kb region of each autosomal arm terminal is the so-called subtelomeric region. Both telomere and subtelomere have high-density...

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PMID: 30687384
DOI: 10.3389/fgene.2018.00697

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