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Human leukocyte telomere length is associated with DNA methylation levels in multiple subtelomeric and imprinted loci

14 May 2014

Abstract excerpt

In humans, leukocyte telomere length (LTL) is positively correlated with lifespan, and shorter LTL is associated with increased risk of age-related disease. In this study we tested for association between telomere length and methylated cytosine levels. Measurements of mean telomere length and DNA methylation at >450,000 CpG sites were obtained for both blood (N = 24) and EBV-transformed cell-line (N = 36) DNA...

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PMID: 24828261
DOI: 10.1038/srep04954

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