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High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations

11 May 2010

Abstract excerpt

B-cell receptor (BCR) diversity is achieved centrally by rearrangement of Variable, Diversity, and Joining genes, and peripherally by somatic hypermutation and class-switching of the rearranged genes. Peripheral B-cell populations are subject to both negative and positive selection events in the course of their development that have the potential to shape the BCR repertoire. The origin of IgM(+)IgD(+)CD27(+) (IgM...

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PMID: 20457872
DOI: 10.1182/blood-2010-03-275859

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