Article
Differential Expression of IgM and IgD Discriminates Two Subpopulations of Human Circulating IgM+IgD+CD27+ B Cells That Differ Phenotypically, Functionally, and Genetically.
Frontiers in immunology - 1 Jan 2020
Bautista Diana, Vásquez Camilo, Ayala-Ramírez Paola, Téllez-Sosa Juan, Godoy-Lozano Ernestina, Martínez-Barnetche Jesús, Franco Manuel, Angel Juana
Abstract excerpt
The origin and function of blood IgM+IgD+CD27+ B cells is controversial, and they are considered a heterogeneous population. Previous staining of circulating B cells of healthy donors with rotavirus fluorescent virus-like particles allowed us to differentiate two subsets of IgM+IgD+CD27+: IgMhi and IgMlo B cells. Here, we confirmed this finding and compared the phenotype, transcriptome, in vitro function, and Ig...
Topics
- Adult
- B-Lymphocyte Subsets
- B-Lymphocytes
- Gene Expression Profiling
- Germinal Center
- Humans
- Immunoglobulin D
- Immunoglobulin Heavy Chains
- Immunoglobulin M
- Immunoglobulin Variable Region