Article
Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age.
Immunology and cell biology - 1 Oct 2017
de Jong Britt G, IJspeert Hanna, Marques Lemelinda, van der Burg Mirjam, van Dongen Jacques Jm, Loos Bruno G, van Zelm Menno C
Abstract excerpt
The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated temporally during an immune response or upon activation in a secondary response. We here aimed to uncouple these processes and to distinguish memory B cells from primary...
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