IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens.

doi:10.1084/jem.20251752

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Article

IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens.

The Journal of experimental medicine - 4 May 2026

Tachó-Piñot Roser, Bashour Habib, Filipska Martyna, Corral-Vazquez Celia, Guzman Mauricio, Marcos-Fa Xavi, Martinuzzi Donata, Honner Hannah, Canales Herrerias Pablo, Tejedor Vaquero Sonia, Sáez Gordón Alba, Perera-Bel Julia, Domínguez Barragán Jorge, Arcos-Ribas Berta, de Campos-Mata Leire, Slabodkin Andrei, Chernigovskaya Maria, Rodríguez de la Concepción Maria Luisa, Gutierrez-Marcos Jose, García-García Ana, Nascimento Osorio Andres, Pascal Mariona, Yagüe Jordi, Juan Manel, Aróstegui Juan Ignacio, Hijano Esqué Rafael, Sánchez Font Albert, Ehl Stephan, Grimbacher Bodo, Rizzi Marta, Dotta Laura, Chen Kang, Badolato Raffaele, Alsina Laia, Mehandru Saurabh, Cunningham-Rundles Charlotte, Carrillo Jorge, Magri Giuliana, Greiff Victor, Cerutti Andrea

Abstract excerpt

Human tonsils from the nasopharyngeal mucosa mount frontline antibody responses, including IgD secretion by IgD+IgM- plasma cells (IgD-PCs). The developmental origins and functional significance of these IgD responses remain poorly understood. Here, we show that most IgD-PCs clonally emerge from a heterogeneous population of IgD class-switched IgD+IgM- memory (IgD-ME) B cells that reside within the epithelial,...

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Immunoglobulin Class Switching

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PMID: 42030438
DOI: 10.1084/jem.20251752

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