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Article

Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life.

European journal of immunology - 1 Dec 1993

Klein U, Küppers R, Rajewsky K

Abstract excerpt

Peripheral blood B cells of a 67-year-old person were separated into IgM+IgD+, IgM+IgD-, and IgM-IgD- subsets, and nucleotide sequences of expressed immunoglobulin light chain variable (V) regions encoded by V kappa 3 and V kappa 4 gene family members were determined from amplified cDNA. V region...

Topics

Aged
Amino Acid Sequence
B-Lymphocyte Subsets
Base Sequence
Gene Expression
Genes, Immunoglobulin
Humans
Immunoglobulin D
Immunoglobulin Joining Region
Immunoglobulin M
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin kappa-Chains

Molecular Sequence Data

Mutation

Source

Identifiers

PMID: 8258343
DOI: 10.1002/eji.1830231232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8258343-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life.PMID 8258343Read ↗

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