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Article

A Reassessment of IgM Memory Subsets in Humans.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2015

Bagnara Davide, Squillario Margherita, Kipling David, Mora Thierry, Walczak Aleksandra M, Da Silva Lucie, Weller Sandra, Dunn-Walters Deborah K, Weill Jean-Claude, Reynaud Claude-Agnès

Abstract excerpt

From paired blood and spleen samples from three adult donors, we performed high-throughput VH sequencing of human B cell subsets defined by IgD and CD27 expression: IgD(+)CD27(+) ("marginal zone [MZ]"), IgD(-)CD27(+) ("memory," including IgM ["IgM-only"], IgG and IgA) and IgD(-)CD27(-) cells ("double-negative," including IgM, IgG, and IgA). A total of 91,294 unique sequences clustered in 42,670 clones, revealing...

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Identifiers

PMID: 26355154
DOI: 10.4049/jimmunol.1500753
PMCID: PMC4594759

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Source receipt: pubmed, retrieved 7 Sept 2026.

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