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Article

Evidence for a Large Compartment of IgM-Expressing Memory B Cells in Humans

15 Feb 1997

Abstract excerpt

The recent finding of somatically mutated mu heavy chain transcripts in human peripheral blood (PB) B lymphocytes suggests that T-dependent B-cell memory might not be restricted to class-switched cells. We provide here evidence that IgM-only PB B cells are likely to be the IgM-expressing counterpart of classical (IgM- IgD-) memory B cells in humans. As shown by molecular single cell analysis, most IgM-only cells...

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Identifiers

PMID: 9028952
DOI: 10.1182/blood.v89.4.1288

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Related research

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Research trail→

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Evidence for a Large Compartment of IgM-Expressing Memory B Cells in HumansPMID 9028952Read ↗

High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populationsSemantic proximity Read ↗

A Reassessment of IgM Memory Subsets in Humans.Semantic proximity Read ↗

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Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells.Semantic proximity Read ↗

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