Article
Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation.
The Journal of experimental medicine - 23 Nov 2009
Seifert Marc, Küppers Ralf
Abstract excerpt
The origin of IgM(+)CD27(+) B lymphocytes with mutated IgV genes, which account for approximately 20% of human peripheral blood (PB) B cells, is controversially discussed. A generation in a primary diversification pathway, in T cell-independent immune responses, or in T cell-dependent germinal center (GC) reactions has been proposed. We show here that IgM(+)IgD(+)CD27(+) and IgM(+)IgD(-/low)CD27(+) B cell subsets...
Topics
- Adult
- B-Lymphocytes
- Base Sequence
- DNA-Binding Proteins
- Germinal Center
- Humans
- Immunoglobulin D
- Immunoglobulin M
- Immunoglobulin Variable Region
- Immunologic Memory
- Molecular Sequence Data