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Article

Serotonin transporter gene polymorphisms and treatment-resistant depression.

Progress in neuro-psychopharmacology & biological psychiatry - 16 Aug 2010

Bonvicini Cristian, Minelli Alessandra, Scassellati Catia, Bortolomasi Marco, Segala Matilde, Sartori Riccardo, Giacopuzzi Mario, Gennarelli Massimo

Abstract excerpt

Major Depression Disorder (MDD) is a serious mental illness that is one of the most disabling diseases worldwide. In addition, approximately 15% of depression patients are defined treatment-resistant (TRD). Preclinical and genetic studies show that serotonin modulation dysfunction exists in patients with TRD. Some polymorphisms in the promoter region of the serotonin transporter gene (SLC6A4) are likely to be...

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Identifiers

PMID: 20450949
DOI: 10.1016/j.pnpbp.2010.04.020

Genes

TRD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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