Serotonin transporter gene (SLC6A4) polymorphisms are associated with response to fluoxetine in south Indian major depressive disorder patients.

doi:10.1007/s00228-016-2099-9

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Article

Serotonin transporter gene (SLC6A4) polymorphisms are associated with response to fluoxetine in south Indian major depressive disorder patients.

European journal of clinical pharmacology - 1 Oct 2016

Manoharan Aarthi, Shewade Deepak Gopal, Rajkumar Ravi Philip, Adithan Surendiran

Abstract excerpt

PURPOSE: Up to 30-40 % of the major depressive disorder patients do not respond sufficiently to antidepressant treatment. Genetic variations in the serotonin transporter gene have been implicated in modulating treatment response to selective serotonin reuptake inhibitors, and this association is influenced by ethnicity. We investigated the influence of serotonin transporter gene variants 5-HTTLPR and rs25531 in...

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PMID: 27439447
DOI: 10.1007/s00228-016-2099-9

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