Article
Development and validation of a high-throughput screening method for two polymorphisms in the serotonin transporter gene.
Molecular diagnosis & therapy - 1 Jan 2009
Eidens Moritz, Weise Alexander, Prause Stefan, Dahmen Norbert, Wunsch Annette, Weber Mathias Max, Forst Thomas, Pfützner Andreas
Abstract excerpt
BACKGROUND AND AIM: The human serotonin (5-hydroxytryptamine) transporter, encoded by the SLC6A4 gene on chromosome 17q11.1-q12, is the cellular reuptake site for serotonin and a site of action for several drugs with central nervous system effects, including both therapeutic agents (e.g. antidepressants) and drugs of abuse (e.g. cocaine). It is known that the serotonin transporter plays an important role in the...
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