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Article

Pharmacogenetic association of bi- and triallelic polymorphisms of SLC6A4 with antidepressant response in major depressive disorder.

Journal of affective disorders - 1 Aug 2020

Ren Feifei, Ma Yufeng, Zhu Xiaochen, Guo Rongjuan, Wang Jialin, He Lijuan

Abstract excerpt

BACKGROUND: Antidepressants (ADs) are the main clinical therapy for depression, but approximately half of users do not get adequate response. The biallelic (5-HTTLPR) and triallelic (5-HTTLPR/rs25531) polymorphisms in SLC6A4 have been frequently investigated, but their associations with ADs response are in controversy. Here, we performed a meta-analysis to assess their modulation effect to ADs response in major...

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Identifiers

PMID: 32421611
DOI: 10.1016/j.jad.2020.04.058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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