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Article

5HTTLPR Genetic Variant and Major Depressive Disorder: A Review.

Genes - 26 Oct 2020

Fratelli Caroline, Siqueira Jhon, Silva Calliandra, Ferreira Eduardo, Silva Izabel

Abstract excerpt

Major Depressive Disorder (MDD) is a disease that involves biological, psychological, and social interactions. Studies have shown the importance of genetics contribution to MDD development. The SCL6A4 protein (5HTTLPR) functions transporting serotonin, a neurotransmitter linked to mood and emotion, to the synaptic cleft. Hence, this study seeks, through a literature review, a better comprehension of the 5HTTLPR...

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Source

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Identifiers

PMID: 33114535
DOI: 10.3390/genes11111260
PMCID: PMC7692865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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