Article
Investigating DRD2 and HTR2A polymorphisms in treatment-resistant schizophrenia: a comparative analysis with other treatment-resistant mental disorders and the healthy state.
European archives of psychiatry and clinical neuroscience - 1 Apr 2026
Del Casale Antonio, Gentile Giovanna, Lardani Simone, Modesti Martina Nicole, Arena Jan Francesco, Zocchi Clarissa, De Luca Ottavia, Parmigiani Giovanna, Angeletti Gloria, Ferracuti Stefano, Preissner Robert, Simmaco Maurizio, Borro Marina, Pompili Maurizio
Abstract excerpt
This study investigates treatment-resistant schizophrenia (TRS) by analysing genetic markers in dopamine and serotonin receptors. Conducted on a cohort of 221 patients with treatment-resistant mental disorders, the research focused on DRD2 and HTR2A gene variants-specifically, rs1801028, rs6314, rs7997012, and rs6311. The findings suggest specific associations between certain genetic variants and TRS. Notably,...