Genetics of serotonin receptors and depression: state of the art.

doi:10.2174/1389450111314050004

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Article

Genetics of serotonin receptors and depression: state of the art.

Current drug targets - 1 May 2013

Fabbri Chiara, Marsano Agnese, Serretti Alessandro

Abstract excerpt

Major depression (MD) is a major health problem, partly due to the incomplete understanding of the pathogenic mechanisms of the disease. Research efforts have mainly focused on alterations in monoaminergic neurotransmission, especially in relation to the serotonergic system, due to its key role in the regulation of mood and related biological functions. Given the high heritability of MD (estimated between 31% and...

Topics

Affect
Animals
Depression
Gene-Environment Interaction
Genetic Predisposition to Disease
Humans
Ligands
Phenotype
Receptor, Serotonin, 5-HT1A
Receptor, Serotonin, 5-HT2A
Receptors, Serotonin
Risk Factors
Serotonin
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 23547754
DOI: 10.2174/1389450111314050004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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