Article
Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10.
Genomics - 1 Mar 2007
Saad Yasser, Garrett Michael R, Manickavasagam Ezhilarasi, Yerga-Woolwine Shane, Farms Phyllis, Radecki Tracy, Joe Bina
Abstract excerpt
The presence of blood pressure (BP) quantitative trait loci (QTL) on rat chromosome 10 has been clearly demonstrated by linkage analysis and substitution mapping. Using congenic strains containing the LEW rat chromosomal segments on the Dahl salt-sensitive (S) rat background, further iterations of congenic substrains were constructed and characterized to fine-map a chromosome 10 region (QTL1) linked to blood...
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